MND Clinical Guide
iOS app by ATIF ELNIL. Medical · ATIF ELNIL
- Store rating
- 0 / 5
- Store rating count
- 0
- Download price
- 9.99 USD
- In-app purchases
- Unknown
- Version
- 1.0
- Listing last refreshed
- 2026-09-10
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Store description excerpt
IMPORTANT: For use by qualified healthcare professionals only. Always seek advice from a qualified clinician before any medical or prescribing decision. MND Clinical Guide is a comprehensive, evidence-based clinical reference for the assessment and management of motor neurone disease — built for neurologists, respiratory physicians, palliative care specialists, and all clinicians caring for people living with MND. DIAGNOSIS & CLASSIFICATION • MND subtypes: ALS, PLS, PMA, PBP, flail arm, flail leg — UMN/LMN involvement, features, prognosis • Gold Coast Criteria 2020 and El Escorial/Awaji criteria explained • ALS-FTD overlap: C9orf72, ECAS screening, capacity implications • Differentials: cervical myelopathy, Kennedy disease, MMN, CIDP, myasthenia gravis, IBM, SMA • Investigations: EMG/NCS, MRI, anti-GM1, genetic panel, respiratory function • ALSFRS-R scale and prognostic factors table DRUG TREATMENT • Riluzole: dosing, food interaction, monitoring protocol, LFT/FBC schedules, stop criteria • Edaravone (Radicava): MCI-186 trial, eligibility, UK named-patient access • Tofersen (Qalsody): FDA-approved 2023 for SOD1-ALS, VALOR & ATLAS trials, pre-symptomatic treatment — why ALL ALS patients should now be SOD1 tested • AMX0035 (Relyvrio): CENTAUR trial, PHOENIX failure, withdrawal September 2024 • Active trials: ION363, C9-ASO, TUDCA, TRICALS SYMPTOM MANAGEMENT • Spasticity: baclofen titration, abrupt cessation warning, respiratory caution • Sialorrhoea: glycopyrronium, amitriptyline, botulinum toxin, salivary irradiation • Pseudobulbar affect, cramps, pain, thick secretions, insomnia, anxiety, depression • Anticipatory medications: morphine, midazolam, glycopyrronium, levomepromazine SC RESPIRATORY MANAGEMENT • FVC sitting/supine, SNIP, PCF, MIP, overnight oximetry — values and NIV thresholds • NIV criteria (NICE NG42). • BiPAP settings, mask selection, bulbar disease considerations • Tracheostomy: UK vs international practice, ethical and withdrawal considerations • Acute failure algorithm — avoid high-flow oxygen alone in MND NUTRITION & DYSPHAGIA • SALT referral, videofluoroscopy, FEES, IDDSI texture levels 0–7 • PEG vs RIG by FVC • Targets: 35–45 kcal/kg/day, protein 1.2–1.5g/kg/day, LIPCAL-ALS high-fat evidence COMMUNICATION & AAC • 4-stage communication decline with interventions at each stage • Voice banking: ModelTalker, VocaliD, ACAT/Acapela — start at diagnosis • AAC: Tobii Dynavox, Grid Pad, iPad Grid 3, eye gaze, BCI referral guidance GENETICS & BIOMARKERS • C9orf72, SOD1, FUS, TDP-43, UBQLN2 — clinical implications for each • TDP-43: pathological hallmark of 97% of all ALS • 6-step genetic testing protocol, NfL as emerging biomarker • UK Concordat on Genetic Testing and Insurance MDT & PALLIATIVE CARE • 10-member MDT roles table with referral timing • Advance care planning: NIV, gastrostomy, DNACPR, LPA, emergency healthcare plan • End of life: morphine for dyspnoea, NIV withdrawal, anticipatory prescribing • Carer support: MND C
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